Cao, Brian, M.D.

Dr. Cao obtained his M.D. from Beijing Medical University, People’s Republic of China, in 1986. On receiving a CDC fellowship award, he was a visiting scientist at the National Center for Infectious Diseases, Centers for Disease Control and Prevention (1991–1994). He next served as a postdoctoral fellow at Harvard (1994–1995) and at Yale (1995–1996). From 1996 to 1999, Dr. Cao was a Scientist Associate in charge of the Monoclonal Antibody Production Laboratory at the Advanced BioScience Laboratories–Basic Research Program at the National Cancer Institute–Frederick Cancer Research and Development Center, Maryland. Dr. Cao joined VARI as a Special Program Investigator in June 1999.

Gao, C.-F., Q. Xie, Y.-W. Zhang, Y. Su, P. Zhao, B. Cao, K. Furge, J. Sun, K. Rex, T. Osgood, A. Coxon, T.L. Burgess, and G.F. Vande Woude. 2009. Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met–driven models of leiomyosarcoma. Molecular Cancer Therapeutics 8(10): 2803–2810.  PubMed   Article  

Knudsen, B.S., P. Zhao, J. Resau, S. Cottingham, E. Gherardi, E. Xu, B. Berghuis, J. Daugherty, T. Grabinski, J. Toro, et al. 2009. A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings. Applied Immunohistochemistry and Molecular Morphology 17(1): 56–67.  PubMed  

Nguyen, M.L., S.R. Crowe, S. Kurella, S. Teryzan, B. Cao, J.D. Ballard, J.A. James, and A.D. Farris. 2009. Sequential B cell epitopes of Bacillus anthracis lethal factor bind lethal toxin–neutralizing antibodies. Infect. Immun. 77(1): 162–169.  PubMed   Article  

Wang, X., and B.B. Cao. 2009. Screening of specific internalization Fab fragments from human naïve phage library by combinational bio-panning. In Therapeutic Antibodies: Methods and Protocols, Antony S. Dimitrov, ed. Methods in Molecular Biology series, Vol. 525. New York: Humana Press, pp. 161–174.

Xie, Y., J. Fan, J. Chen, F.P. Huang, B. Cao, P.K. Tam, and Y. Ren. 2009. A novel function for dendritic cell: clearance of VEGF via VEGF receptor-1. Biochem. Biophys. Res. Commun. 380(2): 243–248.  PubMed   Article  

Xu, N., G. Cai, W. Ye, X. Wang, Y. Li, P. Zhao, A. Zhang, R. Zhang, and B. Cao. 2009. Molecular imaging application of radioiodinated anti-EGFR human Fab to EGFR-overexpressing tumor xenografts. Anticancer Res. 29(10): 4005–4011.  PubMed   Article  

Zhao, P., C. Gao, K. Dykema, K. Furge, Z.Q. Feng, and B. Cao. 2010. Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells. Cancer Letters 291(2): 209-216.  PubMed   Article  

Chen, J., K. Futami, D. Petillo, J. Peng, P. Wang, J. Knol, Y. Li, S.K. Khoo, D. Huang, C.N. Qian, P. Zhao, K. Dykyma, R. Zhang, B. Cao, X.J. Yang, K. Furge, B.O. Williams, and B.T. Teh. 2008. Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One 3(10): e3581.  PubMed   Article  

Xie, Q., R. Thompson, K. Hardy, L. DeCamp, B. Berghuis, R. Sigler, B. Knudsen, S. Cottingham, P. Zhao, K. Dykema, B. Cao, J. Resau, R. Hay, and G.F. Vande Woude. 2008. A highly invasive human glioblastoma pre-clinical model for testing therapeutics. J. Transl. Med 6: 77.  PubMed   Article  

Wang, X., J. Zhu, P. Zhao, Y. Jiao, N. Xu, T. Grabinski, C. Liu, C.K. Miranti, T. Fu, and B.B. Cao. 2007. In vitro efficacy of immuno-chemotherapy with anti-EGFR human Fab-Taxol conjugate on A431 epidermoid carcinoma cells. Cancer Biol. Therapy 6(6): 980-987.  PubMed   Article  

Zhao, P., T. Grabinski, C. Gao, R.S. Skinner, T. Giambernardi, Y. Su, E. Hudson, J. Resau, M. Gross, G.F. Vande Woude, R. Hay, and B. Cao. 2007. Identification of a Met-binding peptide from a phage display library. Clin. Cancer Res. 13(20): 6049-6055.  PubMed   Article  

Tsarfaty, G., G.Y. Stein, S. Moshitch-Moshkovitz, D.W. Kaufman, B. Cao, J.H. Resau, G.F. Vande Woude, and I. Tsarfaty. 2006. HGF/SF increases tumor blood volume: a novel tool for the in vivo functional molecular imaging of Met. Neoplasia 8(5): 344-52.  PubMed   Article  

Hay, R.V., B. Cao, R.S. Skinner, Y. Su, P. Zhao, M.F. Gustafson, C.-N. Qian, B.T. Teh, B.S. Knudsen, J.H. Resau, S. Shen, D.J. Waters, M.D. Gross, and G.F. Vande Woude. 2005. Nuclear imaging of Met-expressing human and canine cancer xenografts with radiolabeled monoclonal antibodies (MetSeek™). Clinical Cancer Research 11(19): 7064s–7069s.  PubMed   Article  

Jiao, Y., P. Zhao, J. Zhu, T. Grabinski, Z. Feng, X. Guan, R.S. Skinner, M.D. Gross, R.V. Hay, H. Tachibana, and B. Cao. 2005. Construction of human naïve Fab library and characterization of anti-Met Fab fragment generated from the library. Molecular Biotechnology 31(1): 41–54.  PubMed   Article  

Ren, Y., B. Cao, S. Law, Y. Xie, P.Y. Lee, L. Cheung, Y. Chen, X. Huang, H.M. Chan, P. Zhao, J. Luk, G. Vande Woude, and J. Wong. 2005. Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clinical Cancer Research 11(17): 6190–6197.  PubMed   Article